References: https://www.ncbi.nlm.nih.gov/pubmed/28106818
https://www.ncbi.nlm.nih.gov/pubmed/27890688
https://www.ncbi.nlm.nih.gov/pubmed/27338458
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737458/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558496/